Lita Chase
Download File - https://fancli.com/2tkBCc
Dr. Ronald Davis, Professor of Biochemistry and Genetics in the Department of Biochemistry, Stanford University School of Medicine, described the development of the instrument. He and the university were unable to identify a company that would produce the instrument for commercial distribution. The instrument was considered too complex and failure-prone, and investigators were not interested in it because it made more oligonucleotides than their research required. Even genome centers said they preferred to purchase oligos rather than make them in-house. Attempts to publish the work in 1993 were rejected on the basis that oligonucleotide synthesis was not new and the research community was not interested in such a machine. Therefore, the instrument was licensed to Protogene, which, in partnership with Life Technologies, used the instrument to synthesize custom oligonucleotides for sale to the molecular biology community. Stanford retains use of the machine, and its use in Davis' lab, for example, to build oligos for a yeast functional genomics study that requires 2 million coupling reactions. Ninety-seven percent of the oligos that are synthesized work in the assays for which they are designed, and therefore no quality control tests are used (see below, page 14).
Ms. Mona Wan, a Senior Licensing Associate in the Office of Technology Licensing at Stanford University, explained that the role of her office is to transfer technology for the public good and generate revenue for the university. She stated that potential licensees contacted by her office concluded that the market for building these instruments for sale was too limited. On the other hand, a company that would license the instrument for in-house use, to produce oligonucleotides for sale, could make a profit while reducing the cost of oligos to a very broad community, resulting in substantial cost savings for research and an increase in the potential to discover new ways to use oligos for research. Therefore the device was licensed to Protogene, a company started by Dr. Thomas Brennan, the inventor, with rights reserved for Stanford to use the device. The university considers this a classic case of successful technology transfer because a large community of users (not just those who could have afforded to purchase the machine) benefitted from the new technology. Ms. Wan stated that no other company has approached the university for a license, although one academic institution has done so.
Neeman, H and Ganote, C and Kalescky, R and Ramadugu, SK and Sherman, AH and Bergstrom, A and Gray, Z and Lemley, E and Romanella, A and Stengel, B and Brunson, D and Guilfoos, B and Moore, BG and Rush, J and Voss, D (2016)The advanced cyberinfrastructure research and education facilitators virtual residency: Toward a national cyberinfrastructure workforce. In: UNSPECIFIED.
Karimi, Hassan A (2016)An Accessible and Personalized Navigation Service for Wheelchair Users. In: Rehabilitation Engineering and Assistive Technology Society of North America, 10 July 2016 - 14 July 2016, Arlington, Virginia.
Collister, Lauren Brittany (2016)Managing Qualitative Data from Online Communities and Sources. In: ULS/iSchool Digital Scholarship Workshop Lecture & Series, Hillman Library, University of Pittsburgh.
Jeng, Wei and He, Daqing and Oh, Jung Sun (2016)Understanding qualitative data sharing practices in social sciences. In: 11th International Digital Curation Conference, 22 February 2016 - 25 February 2016, Mövenpick Hotel, Amsterdam City Centre, Amsterdam. (Unpublished) 59ce067264
https://www.kochhara.com/forum/questions-answers/meksyk-polska